Graffmann, Nina; Adjaye, James; (2022) Editorial for Special Issue: iPS Cells (iPSCs) for Modelling and Treatment of Human Diseases. Cells , 11 (15) , Article 2270. 10.3390/cells11152270.

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Abstract

Human induced pluripotent stem cells (iPSCs) have evolved as a powerful tool to model diseases and study treatment possibilities [1] iPSCs have many advantages over classical disease models, such as animals, cell lines or patient-derived primary cells. They can be generated from any cell of the adult body with limited inconvenience for the patient, especially when urine cells are used as a starting material. Thus, it is easy to obtain cells from any desired genetic background; additionally, rare diseases can be studied using these cells. Using genome-editing techniques, isogenic controls and reporter cell lines can be obtained. These enable the investigation of the genetic basis for certain diseases, and reporter cell lines ensure that the desired cell type can be studied in isolation, as well as in combination with other relevant cell types for the organ. Being of human origin, they have the potential to outperform animal studies with respect to toxicological predictions, as drug metabolism varies substantially between species. However, until now, the lack of maturity of in vitro differentiated cells has limited their use in this field, and more research is needed to close this gap.

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