Silveira, EA;
Vinícius-Souza, G;
Camargo Pereira, C;
De Oliveira, C;
Noll, M;
Pagotto, V;
(2023)
Osteosarcopenia later in life: Prevalence and associated risk factors.
Clinical Nutrition ESPEN
, 58
pp. 213-220.
10.1016/j.clnesp.2023.08.030.
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Abstract
Background and aims: The identification of risk factors for osteosarcopenia in older adults is important for planning preventative strategies in clinical practice. Therefore, our study aimed to investigate the prevalence and risk factors associated with osteosarcopenia in older adults using different diagnostic criteria. / Methods: The sample included 171 community-dwelling older adults with a mean age of 79.4 ± 5.9 years and mean body mass index of 25.67 ± 4.70 kg/m2. We analyzed sociodemographic, biomarkers, lifestyle, and health condition data from participants of the “Projeto Idosos - Goiânia” cohort study. The outcome osteosarcopenia was defined as the simultaneous occurrence of sarcopenia and osteopenia. Osteopenia was diagnosed by low lumbar spine bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA). Sarcopenia was diagnosed using handgrip dynamometry and appendicular skeletal mass index assessed by DEXA following the criteria of the two European consensuses on sarcopenia (2010 and 2018). Two osteosarcopenia outcome variables were evaluated: OsteoSarc1 and OsteoSarc2 using the 2010 and 2018 European sarcopenia consensus criteria, respectively. Multivariate Poisson regression analysis was used to calculate the prevalence ratios (PRs). / Results: The prevalence of OsteoSarc1 and OsteoSarc2 were 12.8% and 7.2%, respectively, with no significant gender differences. OsteoSarc1 was associated with low potassium (PR: 3.39, 95% confidence interval [CI]: 1.10–10.43) and malnutrition (PR: 3.84, 95% CI: 1.78–8.30). OsteoSarc2 was associated with being ≥80 years (PR: 7.64, 95% CI: 1.57–37.07), >4 years of education (PR: 3.25, 95% CI: 1.03–10.22), alcohol consumption (PR: 2.41, 95% CI: 1.01–5.77), low potassium (PR: 2.22, 95% CI: 1.45–6.87), low serum vitamin D (PR: 4.47, 95% CI: 1.68–11.88), and malnutrition (PR: 5.00, 95% CI: 1.06–23.51). / Conclusions: OsteoSarc1 had a higher prevalence. The risk factors associated with the two outcomes were malnutrition and potassium level, as well as other risk factors, such as alcohol consumption and low vitamin D level. These findings may contribute to the prevention or treatment of this health condition in older adults.
| Type: | Article |
|---|---|
| Title: | Osteosarcopenia later in life: Prevalence and associated risk factors |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clnesp.2023.08.030 |
| Publisher version: | https://doi.org/10.1016/j.clnesp.2023.08.030 |
| Language: | English |
| Additional information: | Copyright © 2023 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Older Adults, Vitamin D, Potassium, Malnutrition, Alcohol consumption |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10179883 |
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