Vlachos, Konstantinos;
Letsas, Konstantinos P;
Korantzopoulos, Panagiotis;
Liu, Tong;
Georgopoulos, Stamatis;
Bakalakos, Athanasios;
Karamichalakis, Nikolaos;
... Sideris, Antonios; + view all
(2016)
Prediction of atrial fibrillation development and progression: Current perspectives.
World Journal of Cardiology
, 8
(3)
pp. 267-276.
10.4330/wjc.v8.i3.267.
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Abstract
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Several conventional and novel predictors of AF development and progression (from paroxysmal to persistent and permanent types) have been reported. The most important predictor of AF progression is possibly the arrhythmia itself. The electrical, mechanical and structural remodeling determines the perpetuation of AF and the progression from paroxysmal to persistent and permanent forms. Common clinical scores such as the hypertension, age ≥ 75 years, transient ischemic attack or stroke, chronic obstructive pulmonary disease, and heart failure and the congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, stroke/ transient ischemic attack, vascular disease, age 65-74 years, sex category scores as well as biomarkers related to inflammation may also add important information on this topic. There is now increasing evidence that even in patients with so-called lone or idiopathic AF, the arrhythmia is the manifestation of a structural atrial disease which has recently been defined and described as fibrotic atrial cardiomyopathy. Fibrosis results from a broad range of factors related to AF inducing pathologies such as cell stretch, neurohumoral activation, and oxidative stress. The extent of fibrosis as detected either by late gadolinium enhancement-magnetic resonance imaging or electroanatomic voltage mapping may guide the therapeutic approach based on the arrhythmia substrate. The knowledge of these risk factors may not only delay arrhythmia progression, but also reduce the arrhythmia burden in patients with first detected AF. The present review highlights on the conventional and novel risk factors of development and progression of AF.
| Type: | Article |
|---|---|
| Title: | Prediction of atrial fibrillation development and progression: Current perspectives |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.4330/wjc.v8.i3.267 |
| Publisher version: | http://dx.doi.org/10.4330/wjc.v8.i3.267 |
| Language: | English |
| Additional information: | This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/ licenses/by-nc/4.0/ |
| Keywords: | Atrial fibrillation; development; progression; risk factors; inflammation; fibrosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10180398 |
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