Halicka, Monika;
Vitterso, Axel D;
McCullough, Hayley;
Goebel, Andreas;
Heelas, Leila;
Proulx, Michael J;
Bultitude, Janet H;
(2021)
Prism adaptation treatment for upper-limb complex regional pain syndrome: a double-blind randomized controlled trial.
Pain
, 162
(2)
pp. 471-489.
10.1097/j.pain.0000000000002053.
Preview |
Text
Prism adaptation treatment for upper-limb complex regional pain syndrome a double-blind randomized controlled trial.pdf - Other Download (986kB) | Preview |
Abstract
Initial evidence suggested that people with complex regional pain syndrome (CRPS) have reduced attention to the affected side of their body and the surrounding space, which might be related to pain and other clinical symptoms. Three previous unblinded, uncontrolled studies showed pain relief after treatment with prism adaptation, an intervention that has been used to counter lateralised attention bias in brain-lesioned patients. To provide a robust test of its effectiveness for CRPS, we conducted a double-blind randomized controlled trial of prism adaptation for unilateral upper-limb CRPS-I. Forty-nine eligible adults with CRPS were randomized to undergo 2 weeks of twice-daily home-based prism adaptation treatment (n = 23) or sham treatment (n = 26). Outcomes were assessed in person 4 weeks before and immediately before treatment, and immediately after and 4 weeks after treatment. Long-term postal follow-ups were conducted 3 and 6 months after treatment. We examined the effects of prism adaptation vs sham treatment on current pain intensity and the CRPS symptom severity score (primary outcomes), as well as sensory, motor, and autonomic functions, self-reported psychological functioning, and experimentally tested neuropsychological functions (secondary outcomes). We found no evidence that primary or secondary outcomes differed between the prism adaptation and sham treatment groups when tested at either time point after treatment. Overall, CRPS severity significantly decreased over time for both groups, but we found no benefits of prism adaptation beyond sham treatment. Our findings do not support the efficacy of prism adaptation treatment for relieving upper-limb CRPS-I. This trial was prospectively registered (ISRCTN46828292).
| Type: | Article |
|---|---|
| Title: | Prism adaptation treatment for upper-limb complex regional pain syndrome: a double-blind randomized controlled trial |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/j.pain.0000000000002053 |
| Publisher version: | https://doi.org/10.1097/j.pain.0000000000002053 |
| Language: | English |
| Additional information: | Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain. This is an open access article distributed under the terms of the Creative Commons Attribution-Non CommercialNo Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| Keywords: | Complex regional pain syndrome, Prism adaptation, Randomized controlled trial, Attention, Pain, CRPS symptom severity, Body representation, Neuropsychology, Neglect. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10180623 |
Archive Staff Only
 |
View Item |
