Stirrup, Oliver;
Krutikov, Maria;
Azmi, Borscha;
Monakhov, Igor;
Hayward, Andrew;
Copas, Andrew;
Shallcross, Laura;
(2024)
COVID-19 related mortality and hospital admissions in the VIVALDI study cohort: October 2020-March 2023.
Journal of Hospital Infection
, 143
pp. 105-112.
10.1016/j.jhin.2023.10.021.
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Abstract
Background: Long-term care facilities (LTCFs) were heavily affected by COVID-19 early in the pandemic, but the impact of the virus has reduced over time with vaccination campaigns and build-up of immunity from prior infection. // Objectives: To evaluate the mortality and hospital admissions associated with SARS-CoV-2 in LTCFs in England over the course of the VIVALDI study, from October 2020 to March 2023. // Methods: We included residents aged ≥65 years of participating LTCFs who had available follow-up time within the analysis period. We calculated incidence rates (IR) of COVID-19 linked mortality and hospital admissions per calendar quarter, along with infection fatality ratios (IFR, within 28d) and infection hospitalisation ratios (IHR, within 14d) following positive SARS-CoV-2 test. // Results: A total of 26286 residents were included, with at least one positive test for SARS-CoV-2 in 8513 (32.4%). The IR of COVID-19 related mortality peaked in the first quarter (Q1) 2021 at 0.47 per 1000 person-days (1kpd) (around a third of all deaths), in comparison to 0.10 per 1kpd for Q1 2023 which had a similar IR of SARS-CoV-2 infections. There was a fall in observed IFR for SARS-CoV-2 infections from 24.9% to 6.7% between these periods, with a fall in IHR from 12.1% to 8.8%. The population had high overall IRs for mortality for each quarter evaluated, corresponding to annual mortality probability of 28.8-41.3%. // Conclusions: Standardised real-time monitoring of hospitalisation and mortality following infection in LTCFs could inform policy on the need for non-pharmaceutical interventions to prevent transmission.
| Type: | Article |
|---|---|
| Title: | COVID-19 related mortality and hospital admissions in the VIVALDI study cohort: October 2020-March 2023 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jhin.2023.10.021 |
| Publisher version: | https://doi.org/10.1016/j.jhin.2023.10.021 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Care homes; COVID-19; infection fatality ratio; infection hospitalisation ratio; SARS-CoV-2 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10181278 |
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