Berchio, Cristina;
Annen, Lucie Clementine;
Bouamoud, Ynes;
Micali, Nadia;
(2023)
Temporal dynamics of cognitive flexibility in adolescents with anorexia nervosa: A high-density EEG study.
European Journal of Neuroscience
, 57
(6)
pp. 962-980.
10.1111/ejn.15921.
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Abstract
Impairment in cognitive flexibility is a core symptom of anorexia nervosa (AN) and is associated with treatment resistance. Nevertheless, studies on the neural basis of cognitive flexibility in adolescent AN are rare. This study aimed to investigate brain networks underlying cognitive flexibility in adolescents with AN. To address this aim, participants performed a Dimensional Change Card Sorting task during high-density electroencephalography (EEG) recording. Anxiety was measured with the State–Trait Anxiety Inventory. Data were collected on 22 girls with AN and 23 controls. Evoked responses were investigated using global-spatial analysis. Adolescents with AN showed greater overall accuracy, fewer switch trial errors and reduced inverse efficiency switch cost relative to controls, although these effects disappeared after adjusting for trait and state anxiety. EEG results indicated augmented early visual orienting processing (P100) and subsequent impaired attentional mechanisms to task switching (P300b) in subjects with AN. During task switching, diminished activations in subjects with AN were identified in the posterior cingulate, calcarine sulcus and cerebellum, and task repetitions induced diminished activations in a network involving the medial prefrontal cortex, and several posterior regions, compared with controls. No significant associations were found between measures of cognitive flexibility and anxiety in the AN group. Findings of this study suggest atypical neural mechanisms underlying cognitive flexibility in adolescents with AN. More importantly, our findings suggest that different behavioural profiles in AN could relate to differences in anxiety levels. Future research should investigate the efficacy of cognitive training to rebalance brain networks of cognitive flexibility in AN.
| Type: | Article |
|---|---|
| Title: | Temporal dynamics of cognitive flexibility in adolescents with anorexia nervosa: A high-density EEG study |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ejn.15921 |
| Publisher version: | https://doi.org/10.1111/ejn.15921 |
| Language: | English |
| Additional information: | © 2023 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neurosciences & Neurology, adolescence, anorexia nervosa, cognitive flexibility, ERP, source imaging, POSTERIOR PARIETAL CORTEX, EVENT-RELATED POTENTIALS, CARD SORTING TEST, TRAIT ANXIETY, CENTRAL COHERENCE, EATING-DISORDERS, EXECUTIVE FUNCTIONS, SWITCH COSTS, PERFORMANCE, BULIMIA |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10181852 |
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