Shao, Z;
De Coppi, P;
Michielin, F;
(2023)
Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease.
Frontiers in Chemical Engineering
, 5
, Article 1255783. 10.3389/fceng.2023.1255783.
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Abstract
Lung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical cues in lung organoid engineering to improve their physiological relevance and disease modelling capabilities. We discuss the role of mechanobiology in lung development and homeostasis, as well as the integration of biophysical cues in the design and culture of lung organoids. Furthermore, we explore how these advancements have contributed to the understanding of lung distal diseases pathogenesis. We also discuss the challenges and future directions in harnessing mechanobiology and biophysical cues in lung organoid research. This review showcases the potential of lung organoids as a platform to investigate the underappreciated impacts of biophysical and biomechanical properties in enhancing lung organoids complexity and functionality, and ultimately provide new insight into embryonic lung development and pulmonary distal diseases pathogenesis.
| Type: | Article |
|---|---|
| Title: | Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fceng.2023.1255783 |
| Publisher version: | https://doi.org/10.3389/fceng.2023.1255783 |
| Language: | English |
| Additional information: | Copyright © 2023 Shao, De Coppi and Michielin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | lung organoids, mechanobiology, biophysical cues, lung distal diseases, disease modelling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10181960 |
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