Turcas, A;
Kelly, SM;
Bernier-Chastagner, V;
Bolle, S;
Cameron, A;
Corning, C;
Clementel, E;
... Mandeville, HC; + view all
(2023)
Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience.
Radiotherapy and Oncology
, 187
, Article 109810. 10.1016/j.radonc.2023.109810.
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Abstract
Irradiation of the vertebrae in prepubertal patients, if non-homogenous, can result in future growth deformities including kyphoscoliosis. Vertebral delineation and dosimetry were assessed for 101 paediatric cases reviewed within QUARTET-affiliated trials. Despite the availability of published consensus guidelines, a high variability in vertebral delineation was observed, with impact on dosimetry.
| Type: | Article |
|---|---|
| Title: | Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.radonc.2023.109810 |
| Publisher version: | https://doi.org/10.1016/j.radonc.2023.109810 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Radiotherapy, Pediatrics, Clinical trial, Quality assurance, Vertebrae |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10182201 |
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