Chen, MB;
Javanmardi, Y;
Shahreza, S;
Serwinski, B;
Aref, A;
Djordjevic, B;
Moeendarbary, E;
(2023)
Mechanobiology in oncology: basic concepts and clinical prospects.
Frontiers in Cell and Developmental Biology
, 11
, Article 1239749. 10.3389/fcell.2023.1239749.
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Abstract
The interplay between genetic transformations, biochemical communications, and physical interactions is crucial in cancer progression. Metastasis, a leading cause of cancer-related deaths, involves a series of steps, including invasion, intravasation, circulation survival, and extravasation. Mechanical alterations, such as changes in stiffness and morphology, play a significant role in all stages of cancer initiation and dissemination. Accordingly, a better understanding of cancer mechanobiology can help in the development of novel therapeutic strategies. Targeting the physical properties of tumours and their microenvironment presents opportunities for intervention. Advancements in imaging techniques and lab-on-a-chip systems enable personalized investigations of tumor biomechanics and drug screening. Investigation of the interplay between genetic, biochemical, and mechanical factors, which is of crucial importance in cancer progression, offers insights for personalized medicine and innovative treatment strategies.
| Type: | Article |
|---|---|
| Title: | Mechanobiology in oncology: basic concepts and clinical prospects |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fcell.2023.1239749 |
| Publisher version: | https://doi.org/10.3389/fcell.2023.1239749 |
| Language: | English |
| Additional information: | © 2023 Chen, Javanmardi, Shahreza, Serwinski, Aref, Djordjevic and Moeendarbary. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10182409 |
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