Chowdhury, Rafat;
Moorthy, Myuri;
Smith, Lorna;
Mueller, Christoph A;
Gong, Fiona;
Rogers, Harriet J;
Papoutsaki, Marianthi-Vasiliki;
... Punwani, Shonit; + view all
(2023)
First-in-human in-vivo depiction of paraganglioma metabolism by hyperpolarised 13C-magnetic resonance.
BJR Case Reports
, 9
(6)
, Article 20220089. 10.1259/bjrcr.20220089.
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Abstract
Phaeochromocytomas (PCC) and paragangliomas (PGL), cumulatively referred to as PPGLs, are neuroendocrine tumours arising from neural crest-derived cells in the sympathetic and parasympathetic nervous systems. Predicting future tumour behaviour and the likelihood of metastatic disease remains problematic as genotype–phenotype correlations are limited, the disease has variable penetrance and, to date, no reliable molecular, cellular or histological markers have emerged. Tumour metabolism quantification can be considered as a method to delineating tumour aggressiveness by utilising hyperpolarised 13 C-MR (HP-MR). The technique may provide an opportunity to non-invasively characterise disease behaviour. Here, we present the first instance of the analysis of PPGL metabolism via HP-MR in a single case.
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