Rogers, Harriet J;
Singh, Saurabh;
Barnes, Anna;
Obuchowski, Nancy A;
Margolis, Daniel J;
Malyarenko, Dariya I;
Chenevert, Thomas L;
... Punwani, Shonit; + view all
(2023)
Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition.
European Journal of Radiology
, 162
, Article 110782. 10.1016/j.ejrad.2023.110782.
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Abstract
Purpose: VERDICT (Vascular, Extracellular, Restricted Diffusion for Cytometry in Tumours) MRI is a multi b-value, variable diffusion time DWI sequence that allows generation of ADC maps from different b-value and diffusion time combinations. The aim was to assess precision of prostate ADC measurements from varying b-value combinations using VERDICT and determine which protocol provides the most repeatable ADC. // Materials and Methods: Forty-one men (median age: 67.7 years) from a prior prospective VERDICT study (April 2016–October 2017) were analysed retrospectively. Men who were suspected of prostate cancer and scanned twice using VERDICT were included. ADC maps were formed using 5b-value combinations and the within-subject standard deviations (wSD) were calculated per ADC map. Three anatomical locations were analysed per subject: normal TZ (transition zone), normal PZ (peripheral zone), and index lesions. Repeated measures ANOVAs showed which b-value range had the lowest wSD, Spearman correlation and generalized linear model regression analysis determined whether wSD was related to ADC magnitude and ROI size. // Results: The mean lesion ADC for b0 b1500 had the lowest wSD in most zones (0.18–0.58x10-4 mm2/s). The wSD was unaffected by ADC magnitude (Lesion: p = 0.064, TZ: p = 0.368, PZ: p = 0.072) and lesion Likert score (p = 0.95). wSD showed a decrease with ROI size pooled over zones (p = 0.019, adjusted regression coefficient = -1.6x10-3, larger ROIs for TZ versus PZ versus lesions). ADC maps formed with a maximum b-value of 500 s/mm2 had the largest wSDs (1.90–10.24x10-4 mm2/s). // Conclusion: ADC maps generated from b0 b1500 have better repeatability in normal TZ, normal PZ, and index lesions.
| Type: | Article |
|---|---|
| Title: | Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition |
| Location: | Ireland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ejrad.2023.110782 |
| Publisher version: | https://doi.org/10.1016/j.ejrad.2023.110782 |
| Language: | English |
| Additional information: | Copyright © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Magnetic Resonance Imaging; Prostate Cancer; Diffusion Weighted Imaging; Apparent Diffusion Coefficient; Repeatability |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10183249 |
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