Donaldson, N;
Grego, T;
Lancashire, H;
Prager, J;
Granger, N;
Metcalfe, B;
Taylor, J;
(2023)
A Multielectrode Nerve Cuff for Chronic Velocity Selective Recording in a sheep model.
In:
Proceedings of the 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).
IEEE: Sydney, Australia.
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Abstract
Supra-sacral spinal cord injury (SCI) causes loss of bladder fullness sensation and bladder over-activity, leading to retention and incontinence respectively. Velocity selective recording (VSR) of nerve roots innervating the bladder might enable identification of bladder activity. A 10-electrode nerve cuff for sacral nerve root VSR was developed and tested in a sheep model during acute surgeries and chronic implantation for 6 months. The cuff performed well, with 5.90±1.90 kΩ electrode, and <~800 Ω tissue impedance after 189 days implantation with a stable device and tissues. This is important information for assessing the feasibility of chronic VSR.Clinical Relevance-This demonstrates the manufacturing and performance of a neural interface for chronic monitoring of bladder nerve afferents with applications in urinary incontinence and retention management following SCI.
| Type: | Proceedings paper |
|---|---|
| Title: | A Multielectrode Nerve Cuff for Chronic Velocity Selective Recording in a sheep model |
| Event: | 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) |
| Location: | United States |
| Dates: | 24 Jul 2023 - 27 Jul 2023 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/EMBC40787.2023.10340779 |
| Publisher version: | http://dx.doi.org/10.1109/embc40787.2023.10340779 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Performance evaluation, Electrodes, Biological system modeling, Surgery, Bladder, Recording, Manufacturing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10184265 |
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