Walker, I;
Trompeter, S;
Howard, J;
Williams, A;
Bell, R;
Bingham, R;
Bankes, M;
... Elton, C; + view all
(2021)
Guideline on the peri-operative management of patients with sickle cell disease: Guideline from the Association of Anaesthetists.
Anaesthesia
, 76
(6)
pp. 805-817.
10.1111/anae.15349.
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Abstract
Sickle cell disease is a multisystem disease characterised by chronic haemolytic anaemia, painful vaso-occlusive crises and acute and chronic end-organ damage. It is one of the most common serious inherited single gene conditions worldwide and has a major impact on the health of affected individuals. Peri-operative complications are higher in patients with sickle cell disease compared with the general population and may be sickle or non-sickle-related. Complications may be reduced by meticulous peri-operative care and transfusion, but unnecessary transfusion should be avoided, particularly to reduce the risk of allo-immunisation. Planned surgery and anaesthesia for patients with sickle cell disease should ideally be undertaken in centres with experience in caring for these patients. In an emergency, advice should be sought from specialists with experience in sickle cell disease through the haemoglobinopathy network arrangements. Emerging data suggest that patients with sickle cell disease are at increased risk of COVID-19 infection but may have a relatively mild clinical course. Outcomes are determined by pre-existing comorbidities, as for the general population.
| Type: | Article |
|---|---|
| Title: | Guideline on the peri-operative management of patients with sickle cell disease: Guideline from the Association of Anaesthetists |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/anae.15349 |
| Publisher version: | http://dx.doi.org/10.1111/anae.15349 |
| Language: | English |
| Additional information: | © 2021 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists. 805 This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
| Keywords: | haemoglobinopathy, peri-operative, sickle cell anaemia, sickle cell disease, Anemia, Sickle Cell, Humans, Perioperative Care |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10184640 |
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