Vazquez-Montes, Maria DLA;
Fanshawe, Thomas R;
Stoesser, Nicole;
Walker, A Sarah;
Butler, Christopher;
Hayward, Gail;
(2024)
Epidemiology and microbiology of recurrent UTI in women in the community in Oxfordshire, UK.
JAC-Antimicrobial Resistance
, 6
(1)
, Article dlad156. 10.1093/jacamr/dlad156.
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Abstract
Background: Recurrent urinary tract infection (rUTI) contributes to significant morbidity and antibiotic usage. Objectives: To characterize the age of women experiencing rUTI, the microbiology of rUTIs, and the risk of further rUTIs in Oxfordshire, UK. Patients and methods: We retrospectively analysed de-identified linked microbiology and hospital admissions data (Infections in Oxfordshire Research Database), between 2008 and 2019, including positive urine cultures from women aged ≥16 years in community settings. We defined rUTI as ≥2 positive urine cultures within 6 months or ≥3 within 12 months. Results: Of 201 927 women with urine culture performed, 84 809 (42%) had ≥1 positive culture, and 15 617 (18%) of these experienced ≥1 rUTI over a median (IQR) follow-up of 6 (3–9) years. Women with rUTI were 17.0 (95% CI: 16.3–17.7) years older on average. rUTI was commonest (6204; 40%) in those aged 70–89 years. Post-rUTI, the risk of further UTI within 6 months was 29.4% (95% CI: 28.7–30.2). Escherichia coli was detected in 65% of positive cultures. Among rUTIs where the index UTI was E. coli associated, the second UTI was also E. coli associated in 81% of cases. Conclusions: rUTIs represent a substantial healthcare burden, particularly in women >60 years. One-third of women experiencing rUTI have a further microbiologically confirmed UTI within 6 months.
| Type: | Article |
|---|---|
| Title: | Epidemiology and microbiology of recurrent UTI in women in the community in Oxfordshire, UK |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jacamr/dlad156 |
| Publisher version: | https://doi.org/10.1093/jacamr/dlad156 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10184998 |
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