Benussi, Alberto;
Premi, Enrico;
Grassi, Mario;
Alberici, Antonella;
Cantoni, Valentina;
Gazzina, Stefano;
Archetti, Silvana;
... Genetic Frontotemporal dementia Initiative (GENFI), .; + view all
(2024)
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.
Alzheimer's Research & Therapy
, 16
(1)
, Article 10. 10.1186/s13195-024-01383-1.
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Abstract
Background: The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls.// Methods: A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment.// Results: The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001).// Conclusions: The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.
| Type: | Article |
|---|---|
| Title: | Diagnostic accuracy of research criteria for prodromal frontotemporal dementia |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1186/s13195-024-01383-1 |
| Publisher version: | https://doi.org/10.1186/s13195-024-01383-1 |
| Language: | English |
| Additional information: | © The Author(s), 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Prodromal, MCBMI, Frontotemporal dementia, Diagnostic criteria, Diagnostic accuracy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10185560 |
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