O'Connor, David;
Espejo Valle-Inclán, Jose;
Conde, Lucia;
Bloye, Gianna;
Rahman, Sunniyat;
Costa, Joana R;
Bartram, Jack;
... Mansour, Marc R; + view all
(2024)
Non-coding mutations drive persistence of a founder pre-leukemic clone which initiates late relapse in T-ALL.
Blood
10.1182/blood.2023021906.
(In press).
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1-s2.0-S0006497124001022-main.pdf - Accepted Version Access restricted to UCL open access staff until 10 January 2025. Download (2MB) |
Abstract
T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy.
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