McGettrick, P;
Tinago, W;
O'Brien, J;
Miles, S;
Lawler, L;
Garcia-Leon, A;
Mahon, N;
... All Ireland Infectious Diseases Cohort Study, .; + view all
(2024)
Distinct Inflammatory Phenotypes are associated with subclinical and clinical Cardiovascular disease in People living with HIV.
The Journal of Infectious Diseases
, Article jiae007. 10.1093/infdis/jiae007.
(In press).
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Abstract
Despite inflammation being implicated in cardiovascular disease (CVD) in people with HIV (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype could play an important role. Using principal component analyses and unsupervised hierarchical clustering, we examined 38 biomarkers to identify inflammatory phenotypes in two independent cohorts of PWH. We identified three distinct inflammatory clusters present in both cohorts that associated with altered risk of both subclinical CVD (cohort 1) and prevalent clinical CVD (cohort 2) after adjusting for CVD risk factors. These data support precision medicine approaches to enhance CVD risk assessment in PWH.
| Type: | Article |
|---|---|
| Title: | Distinct Inflammatory Phenotypes are associated with subclinical and clinical Cardiovascular disease in People living with HIV |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiae007 |
| Publisher version: | https://doi.org/10.1093/infdis/jiae007 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2024. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | CVD, Inflammation, Subclinical CAD, Bioprofiles, phenotypes, HIV |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10185692 |
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