Porta, EOJ;
(2023)
Mapping the Evolution of Activity-Based Protein Profiling: A Bibliometric Review.
Advanced Pharmaceutical Bulletin
, 13
(4)
pp. 639-645.
10.34172/apb.2023.082.
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Abstract
Activity-based protein profiling (ABPP) is a chemoproteomic approach that employs small-molecule probes to directly evaluate protein functionality within complex proteomes. This technology has proven to be a potent strategy for mapping ligandable sites in organisms and has significantly impacted drug discovery processes by enabling the development of highly selective small-molecule inhibitors and the identification of new therapeutic molecular targets. Despite being nearly a quarter of a century old as a chemoproteomic tool, ABPP has yet to undergo a bibliometric analysis. In order to gauge its scholarly impact and evolution, a bibliometric analysis was performed, comparing all 1919 reported articles with the articles published in the last five years. Through a comprehensive data analysis, including a 5-step workflow, the most influential articles were identified, and their bibliometric parameters were determined. The 1919 analyzed articles span from 1999 to 2022, providing a comprehensive overview of the historical and current state of ABPP research. This analysis presents, for the first time, the characteristics of the most influential ABPP articles, offering valuable insight into the research conducted in this field and its potential future directions. The findings underscore the crucial role of ABPP in drug discovery and novel therapeutic target identification, as well as the need for continued advancements in the development of novel chemical probes and proteomic technologies to further expand the utility of ABPP.
| Type: | Article |
|---|---|
| Title: | Mapping the Evolution of Activity-Based Protein Profiling: A Bibliometric Review |
| Location: | Iran |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.34172/apb.2023.082 |
| Publisher version: | http://dx.doi.org/10.34172/apb.2023.082 |
| Language: | English |
| Additional information: | © 2023 The Author (s). This is an Open Access article distributed under the terms of the Creative Commons Attribution (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Activity-based probes, Activity-based protein profiling, Affinity-based probes, Bibliometric analysis, Chemical probes, Drug discovery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10185696 |
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