Buckley, Rachel F;
Gong, Jessica;
Woodward, Mark;
(2023)
A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials.
JAMA Neurology
, 80
(8)
pp. 769-770.
10.1001/jamaneurol.2023.1059.
Preview |
Text
Gong_JAMA Neuro editorial manuscript_clean.pdf Download (172kB) | Preview |
Abstract
Historically, scientific findings from male in vitro and in vivo models have formed the standard of medical knowledge. This approach, exacerbated by low female representation in medical research and a dearth of studies investigating sex differences, has led to substantial public health, clinical, and humanitarian implications, as well as economic consequences. A cardinal example from the field of cardiology was the discovery of critical sex-specific treatment effects through ad hoc observational analyses, years after the results of clinical trials had been published. There is a pressing need to study and report sex differences across the field of medicine but most crucially now in Alzheimer disease (AD).
| Type: | Article |
|---|---|
| Title: | A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1001/jamaneurol.2023.1059 |
| Publisher version: | http://dx.doi.org/10.1001/jamaneurol.2023.1059 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10186189 |
Archive Staff Only
 |
View Item |
