van’t Hooft, Jochum J;
Benhamou, Elia;
Albero Herreros, Claudia;
Jiang, Jessica;
Levett, Benjamin;
Core, Lucy B;
Requena-Komuro, Mai-Carmen;
... Warren, Jason D; + view all
(2024)
Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia.
Frontiers in Neurology
, 15
, Article 1341661. 10.3389/fneur.2024.1341661.
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Abstract
Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal dementia (bvFTD). However, this has not been clarified. Methods: 14 consecutive patients with bvFTD fulfilling consensus diagnostic criteria were recruited via a specialist cognitive clinic. Earlier life musical experience, current musical listening habits and general socio-emotional behaviours were scored using a bespoke semi-quantitative musical survey and standardised functional scales, completed with the assistance of patients’ primary caregivers. Associations of musical scores with behavioural scales were assessed using a linear regression model adjusted for age, sex, educational attainment and level of executive and general cognitive impairment. Results: Greater earlier life musical experience was associated with significantly lower Cambridge Behavioural Inventory (Revised) scores (β ± SE = −17.2 ± 5.2; p = 0.01) and higher Modified Interpersonal Reactivity Index (MIRI) perspective-taking scores (β ± SE = 2.8 ± 1.1; p = 0.03), after adjusting for general cognitive ability. Number of hours each week currently spent listening to music was associated with higher MIRI empathic concern (β ± SE = 0.7 ± 0.21; p = 0.015) and MIRI total scores (β ± SE = 1.1 ± 0.34; p = 0.014). Discussion: Musical experience in earlier life and potentially ongoing regular music listening may ameliorate socio-emotional functioning in bvFTD. Future work in larger cohorts is required to substantiate the robustness of this association, establish its mechanism and evaluate its clinical potential.
| Type: | Article |
|---|---|
| Title: | Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2024.1341661 |
| Publisher version: | http://dx.doi.org/10.3389/fneur.2024.1341661 |
| Language: | English |
| Additional information: | Copyright © 2024 van’t Hooft, Benhamou, Albero Herreros, Jiang, Levett, Core, Requena-Komuro, Hardy, Tijms, Pijnenburg and Warren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | musical training, musician, music, frontotemporal dementia, social cognition, behaviour |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10187072 |
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