Davison, Nathan;
Quirk, James A;
Tuna, Floriana;
Collison, David;
McMullin, Claire L;
Michaels, Hannes;
Morritt, George H;
... Lu, Erli; + view all
(2023)
A room-temperature-stable electride and its reactivity: Reductive benzene/pyridine couplings and solvent-free Birch reductions.
Chem
, 9
(3)
pp. 576-591.
10.1016/j.chempr.2022.11.006.
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Abstract
In this work, we report the synthesis of a room-temperature-stable electride (RoSE) reagent, namely K+(LiHMDS)e− (1) (HMDS: 1,1,1,3,3,3-hexamethyldisilazide), from accessible starting materials (potassium metal and LiHMDS) via mechanochemical ball milling at 20 mmol scale. Despite its amorphous nature, the presence of anionic electrons in 1, key diagnostic criteria for an electride, was confirmed by both experimental and computational studies. Therefore, by definition, 1 is an electride. Utilizing its anionic electrons, electride reagent 1 exhibited a versatile reactivity profile that includes (1) mediation of C–H activation and C–C coupling of benzene and pyridine and (2) mediation of solvent-free Birch reduction. This work proves the concept of facile mechanochemical synthesis of a room-temperature-stable electride, and it introduces electride 1 to the synthetic chemistry community as a versatile reagent.
| Type: | Article |
|---|---|
| Title: | A room-temperature-stable electride and its reactivity: Reductive benzene/pyridine couplings and solvent-free Birch reductions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.chempr.2022.11.006 |
| Publisher version: | http://dx.doi.org/10.1016/j.chempr.2022.11.006 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Electride; mechanochemistry; sustainability; organic synthesis; Birch reduction; C–H activation; C–C coupling; benzene; pyridine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10187653 |
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