Elrayes, Mai;
Al Bachari, Sarah;
Macdonagh, Ronan;
Peel, Alex;
Khurshid, Salman;
Hamzah, Juiliana;
Holzmann, Tim;
... Kobylecki, Christopher; + view all
(2024)
Delayed onset post-traumatic wound botulism.
Practical Neurology
10.1136/pn-2023-004036.
(In press).
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Abstract
A 41-year-old man developed rapidly progressive cranial neuropathies and muscle weakness followed by respiratory failure, requiring ventilation support. On examination, there was marked bilateral ptosis and ophthalmoplegia with bulbar, neck and proximal upper limb weakness. He had a recent open left humeral fracture that eventually required amputation. Despite immunoglobulin therapy, his progressive weakness continued. Multiple investigation results were inconclusive. Eventually, botulinum type A toxin was found positive, by which time the therapeutic window for antitoxin had passed. He continued on supportive management and was treated for concomitant infections and nosocomial illnesses. He was subsequently weaned from respiratory support and has made a good neurological recovery.
| Type: | Article |
|---|---|
| Title: | Delayed onset post-traumatic wound botulism |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/pn-2023-004036 |
| Publisher version: | http://dx.doi.org/10.1136/pn-2023-004036 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10188072 |
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