Dadarlat, MC;
Sun, YJ;
Stryker, MP;
(2024)
Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation.
Neuron
, 112
(5)
821-834.e4.
10.1016/j.neuron.2023.11.022.
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Abstract
Electrical stimulation is an effective tool for mapping and altering brain connectivity, with applications ranging from treating pharmacology-resistant neurological disorders to providing sensory feedback for neural prostheses. Paramount to the success of these applications is the ability to manipulate electrical currents to precisely control evoked neural activity patterns. However, little is known about stimulation-evoked responses in inhibitory neurons nor how stimulation-evoked activity patterns depend on ongoing neural activity. In this study, we used 2-photon imaging and cell-type specific labeling to measure single-cell responses of excitatory and inhibitory neurons to electrical stimuli in the visual cortex of awake mice. Our data revealed strong interactions between electrical stimulation and pre-stimulus activity of single neurons in awake animals and distinct recruitment and response patterns for excitatory and inhibitory neurons. This work demonstrates the importance of cell-type-specific labeling of neurons in future studies.
| Type: | Article |
|---|---|
| Title: | Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuron.2023.11.022 |
| Publisher version: | http://dx.doi.org/10.1016/j.neuron.2023.11.022 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | electrical stimulation, 2-photon imaging, awake recordings, cell-type specific, single-cell responses, visual cortex, inhibitory neurons |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10188538 |
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