Caputo, Sergio Lo;
Poliseno, Mariacristina;
Tavelli, Alessandro;
Gagliardini, Roberta;
Rusconi, Stefano;
Lapadula, Giuseppe;
Antinori, Andrea;
... ICONAFoundationStudy Group, .; + view all
(2024)
Heavily Treatment-Experienced Persons Living with HIV Currently in Care in Italy: characteristics, Risk Factors, and Therapeutic Options - the ICONA Foundation Cohort study.
International Journal of Infectious Diseases
, 143
, Article 106956. 10.1016/j.ijid.2024.01.023.
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Abstract
OBJECTIVES: Heavily Treatment-Experienced (HTE) People Living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed to investigate the prevalence and features of HTE individuals followed up inthe ICONA cohort as of December 31, 2021. METHODS: HTE were defined based on meeting specific conditions concerning their current ART and their ART history up to December 31, 2021.Descriptive statistics were performed by HTE status. Regression analyses explored factors associated with becoming HTE based on pre-ART patients' characteristics. Cluster dendrogram analysis provided insights into subgroups with inadequate responses based on CD4 counts and viral load (VL) trajectories Results: Among the 8,758 PLWH actively followed in our cohort, 163 individuals(1.9%),mainly female, younger, Italian, and infected through heterosexual contact,met the HTE criteria. A lower CD4 count at ART initiation (OR 1.60 per 100 cells/mmc lower CD4, 95% CI 1.06-2.41, p=0.03) and HCV Ab positivity (OR 1.90, 95% CI 1.16-3.11, p=0.01) were associated with higher HTE risk. Thirty PLWH exhibited ongoing immune-virological failure (18% of the HTE subgroup and 0.003% of the total population). Thirty PLWH exhibited ongoing immune-virological failure (i.e. with a current CD4 count<200 cells/mmc or VL>200 copies/mL). A cluster analysis identified 13 (43%) with a current CD4 count<200 cells/mmc. Also, notably, 19/30 (63%) had major acquired resistance-associated mutations to at least one ARV drug class. CONCLUSIONS: HTE is rare in our cohort and tends to co-exist with major resistance mutations. A focused investigation into treatment history and immuno-virological response is warranted, particularly given the availability of new ARV drugs.
| Type: | Article |
|---|---|
| Title: | Heavily Treatment-Experienced Persons Living with HIV Currently in Care in Italy: characteristics, Risk Factors, and Therapeutic Options - the ICONA Foundation Cohort study |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2024.01.023 |
| Publisher version: | https://doi.org/10.1016/j.ijid.2024.01.023 |
| Language: | English |
| Additional information: | Copyright © 2024 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Antiretroviral Treatment, HIV, Heavily Treatment-Experienced, Immune-Virological Failure, Resistance Mutations |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10189371 |
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