Levene, I;
Quigley, MA;
Fewtrell, M;
Brien, FO;
(2024)
Does extremely early expression of colostrum after very preterm birth improve mother’s own milk quantity? A cohort study.
Archives of Disease in Childhood: Fetal and Neonatal Edition
10.1136/archdischild-2023-326784.
(In press).
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Abstract
Objective Assess the relationship of time to first expression after very preterm birth and mothers’ own milk quantity. Design A cohort study (nested within a randomised trial). Setting Four neonatal units in the UK. Patients 132 mothers of single or twin infants born at 23+0 to 31+6 weeks postmenstrual age. Exposures Time to the first attempt to express after birth. Primary outcomes 24-hour mother’s own milk yield on days 4, 14 and 21 after birth. Results Median time to first expression attempt was 6 hours. 51.7% expressed within 6 hours of birth (62/120) and 48.3% expressed more than 6 hours after birth (58/120). Expressing within 6 hours of birth was associated with higher milk yield on day 4 (88.3 g, 95% CI 7.1 to 169.4) and day 14 (155.7 g, 95% CI 12.2 to 299.3) but not on day 21 (73.6 g, 95% CI −91.4 to 238.7). There was an interaction between expressing frequency and time to first expression (p<0.005), with increased expressing frequency being associated with higher yield only in those who expressed within 6 hours. Expressing within 2 hours of birth was not associated with further milk yield increase. Conclusions Mothers who expressed within 6 hours of birth had higher milk yield, and a greater yield per expressing session, in the first 3 weeks after birth. This information will be highly motivating for families and the clinicians supporting them. There was no evidence of further benefit of extremely early expression (first 2 hours after birth). Trial registration number ISRCTN 16356650.
| Type: | Article |
|---|---|
| Title: | Does extremely early expression of colostrum after very preterm birth improve mother’s own milk quantity? A cohort study |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/archdischild-2023-326784 |
| Publisher version: | http://dx.doi.org/10.1136/archdischild-2023-326784 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Intensive Care Units, Neonatal, Neonatology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10190234 |
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