Kane, Zoe Anna;
(2024)
Application of mechanistic and mixed effect modelling in the elucidation of developmental factors influencing oral absorption and bioavailability in children.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
Infectious diseases are the major cause of drug use in children, however even today a significant proportion of paediatric medicines lack rational age appropriate dosing strategies. Most paediatric medicines are administered orally which introduces further complexity to paediatric dose setting beyond scaling of drug clearance. There still remain significant gaps in our understanding of the developmental changes that influence oral drug absorption and bioavailability in children especially during the early years of life, a time when the most significant maturational changes occur in the structure and function of the biological systems affecting drug exposure. This PhD comprises three distinct chapters. Each chapter focuses on a different antimicrobial with different absorption, distribution, metabolism and elimination (ADME) properties. Either population (nonlinear mixed effects) and/or physiologically based pharmacokinetic (PK) modelling has been utilised to study the agedependent physiological changes that influence oral drug absorption and bioavailability in children.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Application of mechanistic and mixed effect modelling in the elucidation of developmental factors influencing oral absorption and bioavailability in children |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10190443 |
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