Lacombe, Didier;
Bloch-Zupan, Agnès;
Bredrup, Cecilie;
Cooper, Edward B;
Houge, Sofia Douzgou;
García-Miñaúr, Sixto;
Kayserili, Hülya;
... Hennekam, Raoul C; + view all
(2024)
Diagnosis and management in Rubinstein-Taybi syndrome: first international consensus statement.
Journal of Medical Genetics
10.1136/jmg-2023-109438.
(In press).
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Abstract
Rubinstein-Taybi syndrome (RTS) is an archetypical genetic syndrome that is characterised by intellectual disability, well-defined facial features, distal limb anomalies and atypical growth, among numerous other signs and symptoms. It is caused by variants in either of two genes (CREBBP, EP300) which encode for the proteins CBP and p300, which both have a function in transcription regulation and histone acetylation. As a group of international experts and national support groups dedicated to the syndrome, we realised that marked heterogeneity currently exists in clinical and molecular diagnostic approaches and care practices in various parts of the world. Here, we outline a series of recommendations that document the consensus of a group of international experts on clinical diagnostic criteria for types of RTS (RTS1: CREBBP; RTS2: EP300), molecular investigations, long-term management of various particular physical and behavioural issues and care planning. The recommendations as presented here will need to be evaluated for improvements to allow for continued optimisation of diagnostics and care.
| Type: | Article |
|---|---|
| Title: | Diagnosis and management in Rubinstein-Taybi syndrome: first international consensus statement |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/jmg-2023-109438 |
| Publisher version: | http://dx.doi.org/10.1136/jmg-2023-109438 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Genetic Diseases, Genetics, Inborn, Medical, Mental Disorders, Phenotype |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Psychology and Human Development |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10190644 |
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