Zhang, Bin;
Morgan, Meagan;
Teoh, Xin Yi;
Mackay, Ruth;
Ermler, Sibylle;
Narayan, Roger;
(2024)
Recent advances in 3D printing for in vitro cancer models.
Journal of Applied Physics
, 135
(14)
, Article 140701. 10.1063/5.0200726.
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Abstract
3D printing techniques allow for the precise placement of living cells, biological substances, and biochemical components, establishing themselves as a promising approach in bioengineering. Recently, 3D printing has been applied to develop human-relevant in vitro cancer models with highly controlled complexity and as a potential method for drug screening and disease modeling. Compared to 2D culture, 3D-printed in vitro cancer models more closely replicate the in vivo microenvironment. Additionally, they offer a reduction in the complexity and ethical issues associated with using in vivo animal models. This focused review discusses the relevance of 3D printing technologies and the applied cells and materials used in cutting-edge in vitro cancer models and microfluidic device systems. Future prospective solutions were discussed to establish 3D-printed in vitro models as reliable tools for drug screening and understanding cancer disease mechanisms.
| Type: | Article |
|---|---|
| Title: | Recent advances in 3D printing for in vitro cancer models |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1063/5.0200726 |
| Publisher version: | http://dx.doi.org/10.1063/5.0200726 |
| Language: | English |
| Additional information: | © 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND) license (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | 3D printing, Microfluidic devices, Bioengineering, Pharmaceuticals, Organs, Animal model, Cancer treatment, Cell cultures, Cell lines, 3D bioprinting |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10190882 |
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