Nainggolan, Irwana;
Martina, Sake Juli;
Alva, Sagir;
Li, Bing;
Nasution, Tulus Ikhsan;
Sembiring, Ardiansyah;
Duha, Athaya Samira;
... Asrosa, Rica; + view all
(2024)
Sensitivity of chitosan/reduced graphene oxide/manganese dioxide modified electrodes for cholesterol detection using cyclic voltammetry.
South African Journal of Chemical Engineering
, 48
pp. 329-336.
10.1016/j.sajce.2024.03.009.
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Abstract
Cholesterol detection needs to be carried out to detect early symptoms of dangerous diseases such as heart disease. The process of detecting cholesterol in the human blood requires a sensitive detection tool in order to produce accurate values. This paper reports the performance of chitosan thin films modified with reduced graphene oxide (rGO) and manganese dioxide (MnO2) as the sensitive layer of working electrodes in detecting cholesterol. The electrode substrate is a copper-screen printed electrode (copper-SPE) which was patterned into 5 mm of sensitive area. The chitosan and chitosan-reduced graphene oxide (rGO) matrices were deposited on the top of working electrodes. The characterization of chitosan, chitosan/rGO, and chitosan/rGO/MnO2 thin films was performed using AFM, FE-SEM, and FTIR. The electrochemical sensing properties of modified working electrode were observed using an electrochemical method of cyclic voltammetry (CV). The novelty of this research is the utilization of chitosan/rGO/MnO2 thin film-based working electrode for detecting cholesterol. The testing results indicated that the sensitivity of the modified working electrodes increased when working electrodes based on chitosan/rGO/MnO2 thin film were used for cholesterol detection compared to the working electrodes based on the chitosan thin film. It was proven from the sensitivity of working electrodes based on chitosan/rGO/MnO2 thin film which gave the lowest value of 3.21 × 10−5 µA/µM as well as the ability of working electrodes based on chitosan/rGO/MnO2 thin film which worked at limit of detection (LoD) 0.26 µM/L and limit of quantification (LoQ) 0.87 µM/L. Based on the sensitivity, LoD, and LoQ values, the chitosan/rGO/MnO2 modified electrodes can be used as working electrodes to measure cholesterol concentration in blood.
| Type: | Article |
|---|---|
| Title: | Sensitivity of chitosan/reduced graphene oxide/manganese dioxide modified electrodes for cholesterol detection using cyclic voltammetry |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.sajce.2024.03.009 |
| Publisher version: | http://dx.doi.org/10.1016/j.sajce.2024.03.009 |
| Language: | English |
| Additional information: | © 2024 The Author(s). Published by Elsevier B.V. on behalf of South African Institution of Chemical Engineers. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Chitosan, Cholesterol, Cyclic voltammetry, Manganese dioxide, Reduced graphene oxide |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10190888 |
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