Postiglione, Marco;
Bean, Daniel;
Kraljevic, Zeljko;
Dobson, Richard JB;
Moscato, Vincenzo;
(2024)
Predicting Future Disorders via Temporal Knowledge Graphs and Medical Ontologies.
IEEE Journal of Biomedical and Health Informatics
pp. 1-12.
10.1109/JBHI.2024.3390419.
(In press).
Preview |
Text
Predicting_Future_Disorders_via_Temporal_Knowledge_Graphs_and_Medical_Ontologies.pdf - Accepted Version Download (683kB) | Preview |
Abstract
Despite the vast potential for insights and value present in Electronic Health Records (EHRs), it is challenging to fully leverage all the available information, particularly that contained in the free-text data written by clinicians describing the health status of patients. The utilization of Named Entity Recognition and Linking tools allows not only for the structuring of information contained within free-text data, but also for the integration with medical ontologies, which may prove highly beneficial for the analysis of patient medical histories with the aim of forecasting future medical outcomes, such as the diagnosis of a new disorder. In this paper, we propose MedTKG, a Temporal Knowledge Graph (TKG) framework that incorporates both the dynamic information of patient clinical histories and the static information of medical ontologies. The TKG is used to model a medical history as a series of snapshots at different points in time, effectively capturing the dynamic nature of the patient's health status, while a static graph is used to model the hierarchies of concepts extracted from domain ontologies. The proposed method aims to predict future disorders by identifying missing objects in the quadruple ⟨s,r,?,t⟩ , where s and r denote the patient and the disorder relation type, respectively, and t is the timestamp of the query. The method is evaluated on clinical notes extracted from MIMIC-III and demonstrates the effectiveness of the TKG framework in predicting future disorders and of medical ontologies in improving its performance.
| Type: | Article |
|---|---|
| Title: | Predicting Future Disorders via Temporal Knowledge Graphs and Medical Ontologies |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/JBHI.2024.3390419 |
| Publisher version: | http://dx.doi.org/10.1109/jbhi.2024.3390419 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Temporal knowledge graph, evolutional representation learning, graph convolution network, electronic health records |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10191256 |
Archive Staff Only
 |
View Item |
