Willemsen, Jochem; Rost, Felicitas; Hustinx, Marie; Fonagy, Peter; Taylor, David; (2024) Examination of a case of treatment failure in long-term psychoanalytic psychotherapy for treatment-resistant depression. The International Journal of Psychoanalysis (In press).

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Abstract

Randomized controlled trials have reported psychoanalytic psychotherapy to improve longer-term post-treatment outcomes in patients with treatment-resistant depression. In this case study, we examine the failed (according to the criteria used in the trial) therapy process of a female trial participant diagnosed with treatment-resistant depression. Structured clinical assessments indicated that the patient’s level of depression remained unchanged during and after treatment. Over the course of the therapy, the patient experienced a deterioration of her condition, and she repeatedly broke away from important others and finally also from the therapy itself. In the discussion, we present a variety of reflections that were put forward by the authors during a series of case discussion meetings. Some of these reflections relate to how the inner world of this patient might have triggered a negative therapeutic reaction and a destructive pattern of repetition. The interpretative stance, in which the therapist interpreted this reaction as indicative of a psychic conflict and linked this conflict to the therapeutic relationship, seemed to be experienced by the patient as unhelpful and persecutory. Other elements that were brought up include basic distrust, lack of symbolization and trauma in the patient, as well as the constraints of the research context.

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