Khwaja, Jahanzaib;
Bomsztyk, Joshua;
Atta, Maria;
Bygrave, Ceri;
Forbes, Adam;
Durairaj, Senthil;
Fernandes, Savio;
... Wechalekar, Ashutosh D; + view all
(2024)
Real-world efficacy of single-agent belantamab mafodotin in relapsed systemic AL amyloidosis.
British Journal of Haematology
, 204
(5)
pp. 1811-1815.
10.1111/bjh.19286.
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Abstract
Systemic light chain (AL) amyloidosis is a relapsing plasma cell disorder. Therapy is limited, particularly for triple-class refractory disease. We report the use of belantamab mafodotin, a BCMA-directed drug–antibody conjugate, for relapsed AL amyloidosis, including patients traditionally excluded from clinical trials. Thirty-one patients were reviewed, with a median of three prior lines of therapy. The median follow-up was 12 months (95% CI 4–19), and a median of five doses were delivered. The best haematological overall response rate was 71%, and the complete/very good partial response was 58%. Sixty-eight percent had keratopathy and improved in all. Belantamab mafodotin has high efficacy and good tolerability in patients with relapsed AL amyloidosis.
| Type: | Article |
|---|---|
| Title: | Real-world efficacy of single-agent belantamab mafodotin in relapsed systemic AL amyloidosis |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/bjh.19286 |
| Publisher version: | https://doi.org/10.1111/bjh.19286 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | amyloidosis, antibody therapy, immunotherapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10192138 |
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