Leonardi, Benedetta;
Perrone, Marco;
Calcaterra, Giuseppe;
Sabatino, Jolanda;
Leo, Isabella;
Aversani, Martina;
Bassareo, Pier Paolo;
... Di Salvo, Giovanni; + view all
(2024)
Repaired Tetralogy of Fallot: Have We Understood the Right Timing of PVR?
Journal of Clinical Medicine
, 13
(9)
, Article 2682. 10.3390/jcm13092682.
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Abstract
Despite many advances in surgical repair during the past few decades, the majority of tetralogy of Fallot patients continue to experience residual hemodynamic and electrophysiological abnormalities. The actual issue, which has yet to be solved, is understanding how this disease evolves in each individual patient and, as a result, who is truly at risk of sudden death, as well as the proper timing of pulmonary valve replacement (PVR). Our responsibility should be to select the most appropriate time for each patient, going above and beyond imaging criteria used up to now to make such a clinically crucial decision. Despite several studies on timing, indications, procedures, and outcomes of PVR, there is still much uncertainty about whether PVR reduces arrhythmia burden or improves survival in these patients and how to appropriately manage this population. This review summarizes the most recent research on the evolution of repaired tetralogy of Fallot (from adolescence onwards) and risk factor variables that may favor or delay PVR.
| Type: | Article |
|---|---|
| Title: | Repaired Tetralogy of Fallot: Have We Understood the Right Timing of PVR? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/jcm13092682 |
| Publisher version: | http://dx.doi.org/10.3390/jcm13092682 |
| Language: | English |
| Additional information: | Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Copyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). |
| Keywords: | tetralogy of Fallot; PVR; pulmonary insufficiency |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10192325 |
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