Chambers, Pinkie;
Wagner, Anna Dorothea;
Almossawi, Ofran;
Jenkinson, Simon;
Brooks, Gabriel A;
Bridgewater, John;
(2024)
Biological sex and chemotherapy treatment delays in patients with colorectal cancer.
Colorectal Cancer
, 13
(1)
, Article 2352410. 10.1080/1758194X.2024.2352410.
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Abstract
Aim: We investigated the association of biological sex with the incidence of inter-cycle treatment delays. Patients & methods: This retrospective cohort study included patients receiving first-line chemotherapy. Multivariable logistic regression was used to assess the association between biological sex and a 7-day treatment delay, adjusting for confounders. Results: Among 1904 patients, 1106 (58%) were males and 798 (42%) females. 387 patients (20%) had a treatment delay (54% males, 46% females; p = 0.08). Sex was associated with treatment delays in multivariable analysis (males vs females OR: 0.73, 95% CI 0.57–0.93). Conclusion: The findings are concordant with other studies reporting differences in toxicity profiles of fluorouracil. Further research is required to optimize dosing between males and females.
| Type: | Article |
|---|---|
| Title: | Biological sex and chemotherapy treatment delays in patients with colorectal cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/1758194X.2024.2352410 |
| Publisher version: | https://www.tandfonline.com/journals/icrc20 |
| Language: | English |
| Additional information: | © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10192756 |
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