Zhang, Kevin Y;
Aguzzi, Erika A;
Johnson, Thomas V;
(2021)
Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration.
Cells
, 10
(6)
, Article 1426. 10.3390/cells10061426.
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Abstract
As part of the central nervous system, mammalian retinal ganglion cells (RGCs) lack significant regenerative capacity. Glaucoma causes progressive and irreversible vision loss by damaging RGCs and their axons, which compose the optic nerve. To functionally restore vision, lost RGCs must be replaced. Despite tremendous advancements in experimental models of optic neuropathy that have elucidated pathways to induce endogenous RGC neuroprotection and axon regeneration, obstacles to achieving functional visual recovery through exogenous RGC transplantation remain. Key challenges include poor graft survival, low donor neuron localization to the host retina, and inadequate dendritogenesis and synaptogenesis with afferent amacrine and bipolar cells. In this review, we summarize the current state of experimental RGC transplantation, and we propose a set of standard approaches to quantifying and reporting experimental outcomes in order to guide a collective effort to advance the field toward functional RGC replacement and optic nerve regeneration.
| Type: | Article |
|---|---|
| Title: | Retinal Ganglion Cell Transplantation: Approaches for Overcoming Challenges to Functional Integration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/cells10061426 |
| Publisher version: | http://dx.doi.org/10.3390/cells10061426 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Retinal ganglion cell; optic nerve; neuron; transplantation; regeneration; engraftment; functional integration; stem cells; cell replacement; regenerative medicine |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10193268 |
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