Sampaio Soares, António;
(2024)
Uses of near infrared and spectral imaging in colorectal surgery.
Doctoral thesis (Ph.D), UCL (University College London).
Preview |
Text
Moura Tavares De Sampaio Soares_10193833_thesis_Sig_removed.pdf Download (410MB) | Preview |
Abstract
The integration of minimally invasive surgical techniques with advancements in spectral imaging, fluorescence imaging, and artificial intelligence presents an opportunity to enhance intraoperative data utilisation in colorectal surgery. Addressing challenges such as identifying lymph node drainage patterns and reducing anastomotic leaks is pivotal in this field. This thesis investigates leveraging intraoperative data analysis for lymph node mapping and perfusion assessment in colorectal surgery. Effective lymphatic drainage mapping in colon cancer surgery is achievable with fluorescence imaging. A systematic review revealed considerable technique variability, prompting the documentation of a standardised intracorporeal mapping method. Computational testing of the colonic microperfusion canonical model, using multispectral imaging data pre-anastomosis, challenges the adequacy of the current perfusion paradigm. Fluorescence imaging emerges as a valuable tool for perfusion assessment, with a strong positive correlation observed between tissue oxygen saturation and fluorescence intensity, bolstering its utility in decision-making. However, current perfusion assessment relies on surgeon interpretation, with quantified interobserver variability indicating significant disagreement among respondents, irrespective of experience level or specialisation. In response, three algorithms were developed to enhance standardisation and decision-making in fluorescence angiography. Leveraging both unsupervised and supervised learning techniques, including automated machine learning and convolutional neural networks, the latter demonstrated superior performance and is accessible as an interactive online application. In conclusion, intraoperative data analysis holds promise for supporting surgeons in lymphatic mapping and perfusion assessment during colorectal procedures, facilitating improved outcomes.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Uses of near infrared and spectral imaging in colorectal surgery |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2024. Original content in this thesis is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) Licence (https://creativecommons.org/licenses/by-nc/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10193833 |
Archive Staff Only
 |
View Item |
