Smyrli, Angeliki;
Raveendran, Vishnuga;
Walter, Simone;
Pagarkar, Waheeda;
Field, Nigel;
Kadambari, Seilesh;
Lyall, Hermione;
(2024)
What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review.
Reviews in Medical Virology
, 34
(4)
, Article e2555. 10.1002/rmv.2555.
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Abstract
Congenital cytomegalovirus (cCMV) is among the most common congenital infections globally. Of 85%–90% cCMV‐infected infants without symptoms at birth, 10%–15% develop sequelae, most commonly sensorineural hearing loss (SNHL); their childhood neurodevelopmental outcomes are less well understood. Embase and MEDLINE were searched for publications from 16th September 2016 to 9th February 2024 to identify studies reporting primary data on neurodevelopmental outcomes in children with asymptomatic cCMV (AcCMV), measured using assessment tools or as evaluated by the study investigators, clinicians, educators, or parents. The Newcastle‐Ottawa scale was applied to studies to assess risk of bias. Of 28 studies from 18 mostly high‐income countries, there were 5‐109 children with AcCMV per study and 6/28 had a mean or median age at last follow‐up of ≥5 years. Children with AcCMV had better neurodevelopmental outcomes than children with symptomatic cCMV in 16/19 studies. Of 9/28 studies comparing AcCMV with CMV‐uninfected children, six reported similar outcomes whilst three reported differences limited to measures of full‐scale intelligence and receptive vocabulary among children with AcCMV and SNHL, or more generally in motor impairment. Common limitations of studies for our question were a lack of cCMV‐uninfected controls, heterogeneous definitions of AcCMV, lack of focus on neurodevelopment, selection bias and inadequate follow‐up. There was little evidence of children with AcCMV having worse neurodevelopmental outcomes than CMV‐uninfected children, but this conclusion is limited by study characteristics and quality; findings highlight the need for well‐designed and standardised approaches to investigate long‐term sequelae.
| Type: | Article |
|---|---|
| Title: | What are the neurodevelopmental outcomes of children with asymptomatic congenital cytomegalovirus infection at birth? A systematic literature review |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/rmv.2555 |
| Publisher version: | https://doi.org/10.1002/rmv.2555 |
| Language: | English |
| Additional information: | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. © 2024 The Author(s). Reviews in Medical Virology published by John Wiley & Sons Ltd. |
| Keywords: | Asymptomatic, congenital cytomegalovirus, neurodevelopment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10194006 |
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