Krijnen, Eva A;
Kouwenhoven, Rose-Marie;
Noteboom, Samantha;
Barkhof, Frederik;
Uitdehaag, Bernard Mj;
Klawiter, Eric C;
Steenwijk, Martijn D;
... Koubiyr, Ismail; + view all
(2024)
Subtypes and location of (juxta)cortical lesions relate to cognitive dysfunction in people with multiple sclerosis.
Multiple Sclerosis Journal
10.1177/13524585241260968.
(In press).
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Abstract
Background: Cortical lesion subtypes’ occurrence and distribution across networks may shed light on cognitive impairment (CI) in multiple sclerosis (MS). // Methods: In 332 people with MS, lesions were classified as intracortical, leukocortical or juxtacortical based on artificially generated double inversion-recovery images. // Results: CI-related leukocortical lesion count increases were greatest within sensorimotor and cognitive networks (p < 0.001). Only intracortical lesion count could distinguish between cognitive groups (p = 0.024). Effect sizes were two- to four-fold larger than differences between MS phenotypes. // Conclusion: In CI-MS, leukocortical lesions predominate, whereas intracortical lesions distinguish cognitive groups. Lesions’ grey matter (GM) involvement might be decisive for cognition in MS, surpassing overall disease burden.
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