Patani, Rickie;
(2024)
The role of glial cells in amyotrophic lateral sclerosis.
In: Shaw, Pamela J, (ed.)
International Review of Neurobiology.
(pp. 381-450).
Elsevier
![[thumbnail of IRN_644_VP.pdf]](https://discovery-pp.ucl.ac.uk/style/images/fileicons/text.png) |
Text
IRN_644_VP.pdf - Other Access restricted to UCL open access staff Download (3MB) |
Abstract
Amyotrophic lateral sclerosis (ALS) has traditionally been considered a neuron-centric disease. This view is now outdated, with increasing recognition of cell autonomous and non-cell autonomous contributions of central and peripheral nervous system glia to ALS pathomechanisms. With glial research rapidly accelerating, we comprehensively interrogate the roles of astrocytes, microglia, oligodendrocytes, ependymal cells, Schwann cells and satellite glia in nervous system physiology and ALS-associated pathology. Moreover, we highlight the inter-glial, glial-neuronal and inter-system polylogue which constitutes the healthy nervous system and destabilises in disease. We also propose classification based on function for complex glial reactive phenotypes and discuss the pre-requisite for integrative modelling to advance translation. Given the paucity of life-enhancing therapies currently available for ALS patients, we discuss the promising potential of harnessing glia in driving ALS therapeutic discovery.
| Type: | Book chapter |
|---|---|
| Title: | The role of glial cells in amyotrophic lateral sclerosis |
| DOI: | 10.1016/bs.irn.2024.04.005 |
| Publisher version: | https://doi.org/10.1016/bs.irn.2024.04.005 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10194630 |
Archive Staff Only
 |
View Item |
