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Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments

Stanford, S Clare; Heal, David J; (2023) Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments. In: Handbook of Experimental Pharmacology. (pp. 1-48). Springer: Berlin, Germany. Green open access

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Abstract

Research into the involvement of adrenoceptor subtypes in the cause(s) of psychiatric disorders is particularly challenging. This is partly because of difficulties in developing animal models that recapitulate the human condition but also because no evidence for any causal links has emerged from studies of patients. These, and other obstacles, are outlined in this chapter. Nevertheless, many drugs that are used to treat psychiatric disorders bind to adrenoceptors to some extent. Direct or indirect modulation of the function of specific adrenoceptor subtypes mediates all or part of the therapeutic actions of drugs in various psychiatric disorders. On the other hand, interactions with central or peripheral adrenoceptors can also explain their side effects. This chapter discusses both aspects of the field, focusing on disorders that are prevalent: depression, schizophrenia, anxiety, attention-deficit hyperactivity disorder, binge-eating disorder, and substance use disorder. In so doing, we highlight some unanswered questions that need to be resolved before it will be feasible to explain how changes in the function of any adrenoceptor subtype affect mood and behavior in humans and other animals.

Type: Book chapter
Title: Adrenoceptors: A Focus on Psychiatric Disorders and Their Treatments
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/164_2023_675
Publisher version: http://dx.doi.org/10.1007/164_2023_675
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Adrenoceptor subtypes, Anxiety, Attention-deficit hyperactivity disorder, Binge-eating disorder, Cognition, Depression, Neurogenesis, Opiate/opioid withdrawal syndrome, Schizophrenia
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10194636
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