Stanford, S Clare;
(2022)
Animal Models of ADHD?
In: Stanford, SC and Sciberras, E, (eds.)
New Discoveries in the Behavioral Neuroscience of Attention-Deficit Hyperactivity Disorder.
(pp. 363-393).
Springer: Cham, Switzerland.
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Abstract
To describe animals that express abnormal behaviors as a model of Attention-Deficit Hyperactivity Disorder (ADHD) implies that the abnormalities are analogous to those expressed by ADHD patients. The diagnostic features of ADHD comprise inattentiveness, impulsivity, and hyperactivity and so these behaviors are fundamental for validation of any animal model of this disorder. Several experimental interventions such as neurotoxic lesion of neonatal rats with 6-hydroxydopamine (6-OHDA), genetic alterations, or selective inbreeding of rodents have produced animals that express each of these impairments to some extent. This article appraises the validity of claims that these procedures have produced a model of ADHD, which is essential if they are to be used to investigate the underlying cause(s) of ADHD and its abnormal neurobiology.
| Type: | Book chapter |
|---|---|
| Title: | Animal Models of ADHD? |
| Location: | Germany |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/7854_2022_342 |
| Publisher version: | http://dx.doi.org/10.1007/7854_2022_342 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 5-Choice serial reaction-time test (task), Colobama mouse, Continuous performance test (task), Dopamine transporter gene knockout mouse, Neonatal 6-hydroxydopamine lesioned rat, Neurokinin-1 (NK1) receptor gene knockout mouse, Obesity, Spontaneously hypertensive rat, Tachykinin receptor-1 (TACR1), Animals, Attention Deficit Disorder with Hyperactivity, Behavior, Animal, Disease Models, Animal, Impulsive Behavior, Oxidopamine, Rats |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10194641 |
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