UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives

Li, Dengxiong; Yu, Qingxin; Wu, Ruicheng; Tuo, Zhouting; Wang, Jie; Ye, Luxia; Shao, Fanglin; ... Feng, Dechao; + view all (2024) Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives. Redox Biology , 73 , Article 103208. 10.1016/j.redox.2024.103208. Green open access

[thumbnail of Interactions between oxidative stress and senescence in cancer Mechanisms, therapeutic implications, and future perspectives.pdf]
Preview
Text
Interactions between oxidative stress and senescence in cancer Mechanisms, therapeutic implications, and future perspectives.pdf - Other

Download (4MB) | Preview

Abstract

BACKGROUND: Recently, numerous studies have reported the interaction between senescence and oxidative stress in cancer. However, there is a lack of a comprehensive understanding of the precise mechanisms involved. AIM: Therefore, our review aims to summarize the current findings and elucidate by presenting specific mechanisms that encompass functional pathways, target genes, and related aspects. METHODS: Pubmed and Web of Science databases were retrieved to search studies about the interaction between senescence and oxidative stress in cancer. Relevant publications in the reference list of enrolled studies were also checked. RESULTS: In carcinogenesis, oxidative stress-induced cellular senescence acts as a barrier against the transformation of stimulated cells into cancer cells. However, the senescence-associated secretory phenotype (SASP) is positively linked to tumorigenesis. In the cancer progression stage, targeting specific genes or pathways that promote oxidative stress-induced cellular senescence can suppress cancer progression. In terms of treatment, many current clinical therapies combine with novel drugs to overcome resistance and reduce side effects by attenuating oxidative stress-induced senescence. Notably, emerging drugs control cancer development by enhancing oxidative stress-induced senescence. These studies highlight the complacted effects of the interplay between oxidative stress and senescence at different cancer stages and among distinct cell populations. Future research should focus on characterizing the roles of distinct senescent cell types in various tumor stages and identifying the specific components of SASP. CONCLUSION: We've summarized the mechanisms of senescence and oxidative stress in cancer and provided illustrative figures to guide future research in this area.

Type: Article
Title: Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.redox.2024.103208
Publisher version: https://doi.org/10.1016/j.redox.2024.103208
Language: English
Additional information: © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: SASP, Senescence, Cancer, Aging, Oxidative stress
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10194730
Downloads since deposit
1,116Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item