Mylonakis, Adam;
Driva, Tatiana S;
Lykoudis, Panagis;
Frountzas, Maximos;
Machairas, Nikolaos;
Tsapralis, Dimitrios;
Toutouzas, Konstantinos G;
(2024)
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis.
Annals of Hepato-Biliary-Pancreatic Surgery
, 28
(2)
pp. 125-133.
10.14701/ahbps.23-161.
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Abstract
Undifferentiated carcinoma with osteoclast-like giant cells (UC-OGCs) of the pancreas is a rare neoplasm that accounts for less than 1% of all pancreatic malignancies. The aim of this study was to review the literature regarding UC-OGC, and to highlight its biological behavior, clinicopathologic characteristics, prognosis, and therapeutic options. A systematic review of the literature in PubMed/Medline and Scopus databases was performed (last search October 31st, 2023) for articles concerning pancreatic UC-OGC in the adult population. Fifty-seven studies met the inclusion criteria, involving 69 patients with a male-to-female ratio of 1.1:1 and a mean age of 62.96. Main symptoms included abdominal pain (33.3%), jaundice (14.5%), weight loss (8.7%), while fourteen patients (20.3%) were asymptomatic. Surgical resection was performed in 88.4% of cases. Survival rates at one, three, and five years were 58%, 44.7%, and 37.3% respectively. Sex, age, size (cut-off of 4 cm), location, and adjuvant treatment did not significantly affect patient survival. UC-OGC of the pancreas is a rare subtype of undifferentiated pancreatic carcinoma with a better prognosis than conventional pancreatic ductal adenocarcinoma or undifferentiated carcinoma without giant cells. The establishment of a dedicated patient registry is imperative to further delineate the optimal treatment for this uncommon clinical entity.
| Type: | Article |
|---|---|
| Title: | Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: An individual participant data meta-analysis |
| Location: | Korea (South) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.14701/ahbps.23-161 |
| Publisher version: | http://dx.doi.org/10.14701/ahbps.23-161 |
| Language: | English |
| Additional information: | © 2024 Annals of Hepato-Biliary-Pancreatic Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0). |
| Keywords: | Carcinoma, Osteoclast-like giant cells, Pancreas, Undifferentiated |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10194941 |
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