Sastre-Garriga, Jaume;
Vidal-Jordana, Angela;
Toosy, Ahmed T;
Enzinger, Christian;
Granziera, Cristina;
Frederiksen, Jette;
Ciccarelli, Olga;
... MAGNIMS Study Group; + view all
(2024)
Value of Optic Nerve MRI in Multiple Sclerosis Clinical Management A MAGNIMS Position Paper and Future Perspectives.
Neurology
, 103
(3)
, Article e209677. 10.1212/WNL.0000000000209677.
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Abstract
The optic nerve is frequently involved in multiple sclerosis (MS). However, MRI of the optic nerve is considered optional in the differential diagnosis of optic neuropathy symptoms either at presentation or in established MS. In addition, unlike spinal cord imaging in comparable scenarios, no role is currently recommended for optic nerve MRI in patients presenting with optic neuritis for its confirmation, to plan therapeutic strategy, within the MS diagnostic framework, nor for the detection of subclinical activity in established MS. In this article, evidence related to these 3 aspects will be summarized and gaps in knowledge will be highlighted, including (1) the acquisition challenges and novel sequences that assess pathologic changes within the anterior visual pathways; (2) the clinical implications of quantitative magnetic resonance studies of the optic nerve, focusing on atrophy measures, magnetization transfer, and diffusion tensor imaging; and (3) the relevant clinical studies performed to date. Finally, an algorithm for the application of optic nerve MRI will be proposed to guide future studies aimed at addressing our knowledge gaps.
| Type: | Article |
|---|---|
| Title: | Value of Optic Nerve MRI in Multiple Sclerosis Clinical Management A MAGNIMS Position Paper and Future Perspectives |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1212/WNL.0000000000209677 |
| Publisher version: | http://dx.doi.org/10.1212/wnl.0000000000209677 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Humans, Multiple Sclerosis, Magnetic Resonance Imaging, Optic Nerve, Optic Neuritis, Disease Management |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195112 |
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