Edwards, Lucy;
Waterton, John C;
Naish, Josephine;
Short, Christopher;
Semple, Thomas;
Parker, Geoff JM;
Tibiletti, Marta;
(2023)
Imaging human lung perfusion with contrast media: A meta-analysis.
European Journal of Radiology
, 164
, Article 110850. 10.1016/j.ejrad.2023.110850.
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Abstract
Purpose: To pool and summarise published data of pulmonary blood flow (PBF), pulmonary blood volume (PBV) and mean transit time (MTT) of the human lung, obtained with perfusion MRI or CT to provide reliable reference values of healthy lung tissue. In addition, the available data regarding diseased lung was investigated. Methods: PubMed was systematically searched to identify studies that quantified PBF/PBV/MTT in the human lung by injection of contrast agent, imaged by MRI or CT. Only data analysed by ‘indicator dilution theory’ were considered numerically. Weighted mean (wM), weighted standard deviation (wSD) and weighted coefficient of variance (wCoV) were obtained for healthy volunteers (HV), weighted according to the size of the datasets. Signal to concentration conversion method, breath holding method and presence of ‘pre-bolus’ were noted. Results: PBV was obtained from 313 measurements from 14 publications (wM: 13.97 ml/100 ml, wSD: 4.21 ml/100 ml, wCoV 0.30). MTT was obtained from 188 measurements from 10 publications (wM: 5.91 s, wSD: 1.84 s wCoV 0.31). PBF was obtained from 349 measurements from 14 publications (wM: 246.26 ml/100 ml ml/min, wSD: 93.13 ml/100 ml ml/min, wCoV 0.38). PBV and PBF were higher when the signal was normalised than when it was not. No significant differences were found for PBV and PBF between breathing states or between pre-bolus and no pre-bolus. Data for diseased lung were insufficient for meta-analysis. Conclusion: Reference values for PBF, MTT and PBV were obtained in HV. The literature data are insufficient to draw strong conclusions regarding disease reference values.
| Type: | Article |
|---|---|
| Title: | Imaging human lung perfusion with contrast media: A meta-analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ejrad.2023.110850 |
| Publisher version: | http://dx.doi.org/10.1016/j.ejrad.2023.110850 |
| Language: | English |
| Additional information: | /© 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Radiology, Nuclear Medicine & Medical Imaging, Lung perfusion, Mean Transit Time, Pulmonary Blood Flow, Pulmonary Blood Volume, Indicator dilution theory, QUANTITATIVE PULMONARY PERFUSION, DUAL-ENERGY CT, DIAPHRAGMATIC-HERNIA REPAIR, BLOOD-FLOW, 2-YEAR-OLD CHILDREN, DYNAMIC PERFUSION, BOLUS APPROACH, WHOLE-LUNG, MRI, QUANTIFICATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195451 |
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