Wong, Geoffrey Yuet Mun;
Wadhawan, Himanshu;
Roth Cardoso, Victor;
Bravo Merodio, Laura;
Rajeev, Yashasvi;
Maldonado, Ricardo David;
Martinino, Alessandro;
... Mahawar, Kamal; + view all
(2024)
30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE).
Annals of Surgery
10.1097/sla.0000000000006236.
(In press).
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Abstract
Objective: This study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications. / Summary Background Data: Although cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level. / Methods: A prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes. / Results: Data of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B–E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications. / Conclusion: This multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.
| Type: | Article |
|---|---|
| Title: | 30-day Morbidity and Mortality after Cholecystectomy for Benign Gallbladder Disease (AMBROSE) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/sla.0000000000006236 |
| Publisher version: | https://doi.org/10.1097/sla.0000000000006236 |
| Language: | English |
| Additional information: | Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
| Keywords: | cholecystectomy, benign gallbladder disease, morbidity, mortality, bile duct injury, complications |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195533 |
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