Dayan, Victor;
Grant, Stuart W;
Brophy, James M;
Barili, Fabio;
Freemantle, Nick;
(2024)
Composite end points and competing risks analysis.
Interdisciplinary CardioVascular and Thoracic Surgery
, 39
(1)
, Article ivae126. 10.1093/icvts/ivae126.
Preview |
Text
Freemantle_ivae126.pdf Download (447kB) | Preview |
Abstract
Composite end points are common primary outcomes in clinical trials. Their main benefit of utilizing a composite outcome is increasing the number of primary outcome events, meaning fewer participants are required to deliver an adequately powered trial. By combining multiple important end points in the primary outcome rather than having to select only 1, composite end points potentially make clinically meaningful benefits easier to detect and avoid ranking outcomes hierarchically. However, there are a number of important considerations when designing and interpreting clinical trials that utilize composite end points. In this Statistical Primer, issues with composite end points such as competing events, halo effect, risk of bias, time-to-event limitations and the win ratio are discussed in the context of real world clinical trials.
| Type: | Article |
|---|---|
| Title: | Composite end points and competing risks analysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/icvts/ivae126 |
| Publisher version: | http://dx.doi.org/10.1093/icvts/ivae126 |
| Language: | English |
| Additional information: | Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Composite outcomes, Competing risks, Statistics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > Comprehensive CTU at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195657 |
Archive Staff Only
 |
View Item |
