Tandirerung, Fistra J;
Jamieson, Alexandra;
Hendrick, Elizabeth;
Hughes, Alun D;
Jones, Siana;
(2024)
Near-infrared spectroscopy (NIRS) in vivo assessment of skeletal muscle oxidative capacity: a comparison of results from short versus long exercise protocols and reproducibility in non-athletic adults.
Frontiers in Physiology
, 15
, Article 1429673. 10.3389/fphys.2024.1429673.
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Abstract
Background: Near-infrared spectroscopy (NIRS) provides a non-invasive, cost-effective method for assessing skeletal muscle oxidative capacity when combined with a short exercise protocol and arterial occlusions. However, the impact of different exercise protocols and reproducibility of the method in non-athletic adults have not previously been assessed. // Methods: Young, non-athletic adults (YA) were invited to perform a short duration, fast frequency contraction (SF) exercise protocol and a long duration slow frequency (LS) contraction protocol, combined with NIRS measurements and arterial occlusions to assess skeletal muscle oxidative capacity. YA and older non-athletic adults (OA; >65 years old) were invited to perform the SF exercise protocol twice to assess the reproducibility of this oxidative capacity measurement. // Results: We included 25 participants (14 male (56%), age range: 18–86 years) in the analyses. There was a strong positive correlation and good agreement between time constants derived following the SF and LS exercise protocols (Lin’s concordance correlation coefficient: 0.69, p-value < 0.001 mean bias [LoA]: −3.2 [−31.0, 24.4] seconds. There was a strong positive correlation and good agreement between time constants derived from the SF exercise protocol in the YA & OA group (Lin’s concordance correlation coefficient: 0.63, p-value < 0.001; mean bias [LoA] −6.4 [−34.0, 21.3] seconds). // Conclusion: These data provide evidence to suggest that NIRS is a reliable in vivo method for the assessment of skeletal muscle oxidative capacity irrespective of exercise protocol duration or muscle contraction frequency. NIRS-measured oxidative capacity via the SF exercise protocol was reproducible in non-athletic adults with a wide range in age.
| Type: | Article |
|---|---|
| Title: | Near-infrared spectroscopy (NIRS) in vivo assessment of skeletal muscle oxidative capacity: a comparison of results from short versus long exercise protocols and reproducibility in non-athletic adults |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fphys.2024.1429673 |
| Publisher version: | http://dx.doi.org/10.3389/fphys.2024.1429673 |
| Language: | English |
| Additional information: | Copyright © 2024 Tandirerung, Jamieson, Hendrick, Hughes and Jones. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Near-infrared spectroscopy, skeletal muscle, oxidative capacity, exercise near-infrared spectroscopy, exercise |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195708 |
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