Lumley, Sheila;
Barlow, Maeve;
Said, Khadija;
Martyn, Emily;
Waddilove, Elizabeth;
Delphin, Marion;
Jennings, Daisy;
... Matthews, Philippa Clare; + view all
(2024)
Multiple risk factors for persistent HBV viraemia in an adult receiving nucleos/tide analogue therapy.
Sexually Transmitted Infections
, 100
(5)
pp. 329-331.
10.1136/sextrans-2024-056168.
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Abstract
Diagnosing and treating chronic hepatitis B virus (HBV) infection are key interventions to support progress towards elimination of viral hepatitis by 2030. Although nucleos/tide analogue (NA) therapy is typically highly effective, challenges remain for viral load (VL) suppression, including medication access, incomplete adherence and drug resistance. We present a case of a long-term HBV and HIV coinfected adult prescribed with sequential NA therapy regimens, with episodes of breakthrough viraemia. Multiple factors contribute to virological breakthrough, including exposure to old NA agents, initial high HBV VL, therapy interruptions, intercurrent illnesses and potential contribution from resistance mutations. The case underscores the importance of individualised treatment approaches and adherence support in achieving HBV suppression. Furthermore, it emphasises the need for improved clinical pathways addressing education, support and access to care, particularly for marginalised populations. Comprehensive data collection inclusive of under-represented individuals is crucial for maintaining retention in the care cascade and informing effective interventions.
| Type: | Article |
|---|---|
| Title: | Multiple risk factors for persistent HBV viraemia in an adult receiving nucleos/tide analogue therapy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1136/sextrans-2024-056168 |
| Publisher version: | http://dx.doi.org/10.1136/sextrans-2024-056168 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10195716 |
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