Naeem, Aishath N; Ghoreishizadeh, Sara S; (2024) False Sensitivities in Cortisol Immunosensors Fabricated on Gold-Screen-Printed Electrodes. In: Proceedings of the 2024 BioSensors Conference (BioSensors). IEEE (Institute of Electrical and Electronics Engineers): Cambridge, UK. (In press).

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Abstract

Cortisol electrochemical sensors are extensively studied since the ability to measure cortisol in real-time would provide information about abnormalities in cortisol levels and how they may affect a variety of processes in which cortisol is involved in the body. The main base layer material and redox mediator utilized in cortisol immunosensors in the literature are gold and ferri/ferrocyanide, respectively. However, this electrolyte-electrode combination is known to cause false positive or negative results, limiting the accuracy of measurements. In this work, three ways through which this electrolyteelectrode system can cause false sensitivities are experimentally demonstrated. The results show that the adsorption of chloride ions and ferri/ferrocyanide redox probe to the surface can alone be responsible for up to 40% of normalized change in sensor output. The ferri/ferrocyanide redox couple can also cause faulty readings by interfering with the sensor structure and etching the gold electrode surface.

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